David Sinclair: “Lifespan: Why We Age and Why We Don’t Have To” | Talks at Google
David Sinclair, professor of genetics at Harvard Medical School, discusses his new book “Lifespan”, which distills his cutting-edge research findings on the biological processes underpinning aging. Sinclair describes lifestyle hacks we can undertake now to combat aging, as well as future scientific breakthroughs that promise to slow down—and even reverse—the aging process.
2:03 - The point is not living forever. Why we don’t call aging a medical condition (yet)
3:07 - WHO and aging as a medical condition
3:58 - “Naturalistic fallacy” (a kind of)
4:30 - Room surveys
5:13 - THE POINT of living well
6:20 - Why we age.
8:30 Aging is simply a loss of information (information theory of aging)
17:30 - Methylome
19:30 - Shannon entropy
21:37 - “We are open system: we can use energy to reset the system.”
22:00 - Yamanaka - cellular reprogramming
23:13 - David’s lab recent discovery: age reversal
28:10 - What we can do right now.
28:55 mice running with epic music XD
30:02 - What you can do right now without taking metformin: EAT LESS OFTEN.
31:20 - Clinical trials right now, molecule-related NMN
32:56 - Father case (not a clinical trial)
34:50 - Q/A session
34:50 role of insuline in aging process (mTOR pathway etc)
37:06 is (intra/extra-cellular) accumulation of junk supposed to be downstream of mentioned mechanisms? [Yes - and the answer is the most interesting of the whole talk]
39:21 is oxidative damage downstream or upstream?
41:50 extracellular collagen damage. --> (deep cleaning, autophagy, fasting)
42:55 Why not more clinical trials on NMN and intermittent fasting as anti-age treatments since doctors secretly seems to use those? [probabily 15-20 trials in progress]
45:26 Which epigenetic factors are more important in biological clock, methylation or other?
48:55 In the twin mice experiment, they keep the same lifespan?
49:59 If this technology work, how does the world look like? [lot of ethical things]
52:28 NMN vs NR?
